The International Spinal Cord Regeneration Center, following the work of Wolfram Kuhnau, has been at the vanguard of clinical assistance to those suffering from spinal cord injury. Its work is offering more than hope to those paralyzed by their injury.
Dr Fernando Ramirez del Rio heads up the clinic which is situated in Tjiuana, Mexico. The clinic is five hundred meters from the border of San Diego, California. Use is made of Xenotransplants - which are essentially embryonic cells from a blue shark.
Although the use of embryonic cell xenotransplantation is the most controversial aspect of this work, its success lies in the fact that the procedure, taken in its totality, is a combination of several interventions, most of which are already well known and which fall within the spectrum of conservative medical protocol. Our observations have led to the conclusion that decompression and reconstructive surgery, which renormalizes the supporting spinal column, combined with the microsurgical removal of scarring tissue and the introduction of a specialized cyst-draining shunt developed by Dr. Carlos Romero, chief neurosurgeon, each combine to optimize the xenotransplant therapy.
Decompression surgery by itself is insufficient, however. This is demonstrated by the work of Dr. Romero, who before joining ISCRC had performed more than 500 decompression procedures. He found the results lacking, as many of our patients have also. They come to us having had some form of surgical intervention shortly after their injury, are diagnosed by their original treating facility as being complete but not transected, and have made but minor progress. They are looking for something more. It was not until the traditional decompression procedures were combined with embryonic cell therapy that Dr. Romero and our treatment team began to see more concrete signs for hope.
In summary, both human clinical observation and an increasing body of basic research is supporting the essential postulates that 1) new neural growth does occur within the mammalian CNS and the peripheral spinal cord as the result of transplantation, 2) that mechanisms inherent to neural cells serve to orient cell growth spatially in non-random patterns, which allows for excitation and transmission of sensory and motor signals, 3) that increasing levels of sensory and motor function are made possible through embryonic xenotransplants, and 4) this increase in normal neural function can be measured in human subjects by evaluation procedures such as the evoked sensory potential test that bypasses the patients conscious awareness of sensory excitation and reception, thereby answering the potential criticism that a patient will respond affirmatively to evaluations of function as a means to please the investigator.
In conclusion, our work is demonstrating that a combination of procedures that includes 1) decompression surgery, 2) microsurgical removal of scarring tissue, 3) orthopedic reconstruction of the boney spinal structures to support renormalization, 4) cyst reducing shunts, and 5) the transplantation of embryonic cells from the first trimester of Blue shark gestation at the injury site of a human subject, combined with 6) a systematic program of physical rehabilitation therapy, is not only safe but effective in the treatment of paraplegia in selected cases in which at least 25% of the original neural mass remains across an injury site with an intact dura mater.
In essence, the treatment protocol is as follows:
Bi-weekly injection into the spineous process below the level of sensation of embryonic brain stem cells and embryonic spinal cord cells.
Daily injections of nerve growth factor
Daily intake of 4-AP
Daily intake of Vitamin C and Vitamin B